Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Multiparticulate Drug Delivery Systems for Controlled Release

N S Dey , S Majumdar, MEB Rao

Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasinghi, Berhampur, Orissa760010, India.;

For correspondence:- N Dey Email: niladrisekhar111@gmail.com Tel:+91-09861352986

Published: 20 September 2008

Citation: Dey NS, Majumdar S, Rao M. Multiparticulate Drug Delivery Systems for Controlled Release. Trop J Pharm Res 2008; 7(3):1067-1075 doi: 10.4314/tjpr.v7i3.9

© 2008 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Pharmaceutical invention and research are increasingly focusing on delivery systems which enhance desirable therapeutic objectives while minimising side effects. Recent trends indicate that multiparticulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from microparticles depends on a variety of factors including the carrier used to form the multiparticles and the amount of drug contained in them. Consequently, multiparticulate drug delivery systems provide tremendous opportunities for designing new controlled and delayed release oral formulations, thus extending the frontier of future pharmaceutical development.

Keywords: Dose dumping, Microparticles, Multiparticulate delivery system, Delayed release.